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| Clearwater $25,000 | Feb 4 2001 |
| Qual 1 | Serra-Zanetti(2) - Jean Okada | 7-5 6-2 |
| Qual 2 | Hana Sromova - Serra-Zanetti(2) | 6-4 6-2 |
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| Rockford $25,000 | Feb 11 2001 |
| Qual 1 | Serra-Zanetti(1) - Nicole Rencken | 7-5 7-62 |
| Qual 2 | Serra-Zanetti(1) - Annica Cooper | 6-1 6-2 |
| Qual 3 | Serra-Zanetti(1) - Joanne Moore(5) | 3-6 6-3 6-2 |
| 1 | Serra-Zanetti-Q - Eva Krejcova | 6-3 6-2 |
| 2 | Serra-Zanetti-Q - Maureen Drake(7) | 6-0 6-1 |
| QF | Serra-Zanetti-Q - Alina Jidkova(1) | 6-70 6-1 6-1 |
| SF | Serra-Zanetti-Q - Yoon-Jeong Cho(8) | 6-2 6-1 |
| F | Jill Craybas(4) - Serra-Zanetti-Q | 6-4 6-3 |
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| Midland $75,000 | Feb 18 2001 |
| Qual 1 | Serra-Zanetti - Jana Hlavackova | 6-2 6-0 |
| Qual 2 | Serra-Zanetti - Valentina Sassi | 6-1 6-3 |
| Qual 3 | Serra-Zanetti - Tatiana Kovalchuk(4) | 6-3 6-4 |
| 1 | Serra-Zanetti-Q - Maureen Drake | 6-3 6-3 |
| 2 | Serra-Zanetti-Q - Alina Jidkova(3) | 6-4 6-3 |
| QF | Yoon-Jeong Cho - Serra-Zanetti-Q | 6-4 4-6 7-5 |
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| Minneapolis $50,000 | Mar 4 2001 |
| Qual 1 | Serra-Zanetti(1) - Andrea Nathan | 6-0 6-0 |
| Qual 2 | Serra-Zanetti(1) - Jacqueline Trail | 6-4 6-1 |
| Qual 3 | Serra-Zanetti(1) - Jolene Watanabe-Giltz(5) | 6-0 6-0 |
| 1 | Serra-Zanetti-Q - Petra Rampre | 6-4 5-7 6-2 |
| 2 | Yvette Basting(2) - Serra-Zanetti-Q | 3-6 7-5 6-0 |
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| Stone Mountain $25,000 | Apr 1 2001 |
| 1 | Serra-Zanetti - Mi-Ra Jeon-LL | 7-5 6-1 |
| 2 | Evie Dominikovic(1) - Serra-Zanetti | 6-2 6-1 |
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| West Palm $75,000 | Apr 8 2001 |
| Qual 1 | Serra-Zanetti - Alicia Molik(3) | 7-5 4-6 6-1 |
| Qual 2 | Serra-Zanetti - Jessica Steck | 6-2 7-5 |
| Qual 3 | Serra-Zanetti - Marion Maruska(8) | 6-1 6-1 |
| 1 | Asa Svensson - Serra-Zanetti-Q | 6-3 6-0 |
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| Columbus $25,000 | Apr 15 2001 |
| 1 | Serra-Zanetti(4) - Jacqueline Trail | 6-4 5-7 7-5 |
| 2 | Serra-Zanetti(4) - Melissa Middleton | 6-4 6-2 |
| QF | Serra-Zanetti(4) - Christina Wheeler(8) | 5-7 7-65 6-3 |
| SF | Mashona Washington(2) - Serra-Zanetti(4) | 6-3 6-2 |
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| Charleston Tier I Clay | Apr 22 2001 |
| Qual 1 | Serra-Zanetti(9) - Jacqueline Trail | 6-1 6-0 |
| Qual 2 | Serra-Zanetti(9) - Renata Kolbovic(7) | 6-4 6-1 |
| 1 | Serra-Zanetti-Q - Jing-Qian Yi-Q | 6-4 7-5 |
| 2 | Gala Leon-Garcia(14) - Serra-Zanetti-Q | 6-1 6-4 |
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| Fed Cup Week1 | Apr 28 2001 |
| | Serra-Zanetti - Silvija Talaja-cro | 6-1 6-1 |
| | Serra-Zanetti - Jelena Kostanic Tosic-cro | 6-1 7-65 |
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| Taranto $25,000 | May 6 2001 |
| 1 | Serra-Zanetti(2) - Scarlett Werner-Q | 6-2 6-2 |
| 2 | Tatiana Kovalchuk - Serra-Zanetti(2) | 7-5 6-3 |
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| Rome Tier I Clay | May 20 2001 |
| 1 | Daniela Hantuchova-Q - Serra-Zanetti-WC | 6-73 6-2 6-4 |
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| Roland Garros Clay | Jun 10 2001 |
| Qual 1 | Serra-Zanetti - Mashona Washington(24) | 6-4 6-2 |
| Qual 2 | Serra-Zanetti - Stéphanie Cohen-Aloro-WC | 6-4 6-4 |
| Qual 3 | Serra-Zanetti - Wynne Prakusya(6) | 6-4 6-4 |
| 1 | Amy Frazier - Serra-Zanetti-Q | 6-2 6-0 |
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| Galatina $25,000 Hard | Jun 10 2001 |
| 1 | Eva Fislova - Serra-Zanetti(3) | 6-1 6-0 |
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| Birmingham Tier III Grass | Jun 17 2001 |
| Qual 1 | Serra-Zanetti(14) - Gabriela Volekova | 4-6 6-0 6-0 |
| Qual 2 | Serra-Zanetti(14) - Jessica Steck | 6-2 6-2 |
| 1 | Serra-Zanetti-Q - Kristie Boogert-LL | 6-4 6-4 |
| 2 | Anastasia Myskina - Serra-Zanetti-Q | 1-6 7-65 6-3 |
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| Wimbledon Grass | Jul 8 2001 |
| Qual 1 | Serra-Zanetti(20) - Sophie Georges | 6-1 1-0 |
| Qual 2 | Serra-Zanetti(20) - Tara Snyder | 6-4 6-4 |
| Qual 3 | Serra-Zanetti(20) - Jing-Qian Yi | 6-4 6-4 |
| 1 | Serra-Zanetti-Q - Henrieta Nagyova(24) | 7-64 6-1 |
| 2 | Iroda Tulyaganova - Serra-Zanetti-Q | 6-3 6-76 6-2 |
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| Orbetello $50,000 | Jul 8 2001 |
| 1 | Serra-Zanetti - Katalin Marosi | 6-4 2-6 6-4 |
| 2 | Galina Fokina-Q - Serra-Zanetti | 7-5 6-2 |
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| Palermo Tier V Clay | Jul 15 2001 |
| 1 | Virginia Ruano Pascual - Serra-Zanetti | 6-0 6-2 |
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| Fed Cup Week2 | Jul 21 2001 |
| | Sandrine Testud-fra - Serra-Zanetti | 6-4 7-5 |
| | Amélie Mauresmo-fra - Serra-Zanetti | 6-2 6-0 |
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| Toronto Tier I Hard | Aug 19 2001 |
| Qual 1 | Serra-Zanetti(14) - Diana Srebrovic-WC | 6-1 6-4 |
| Qual 2 | Serra-Zanetti(14) - Marie-Eve Pelletier | 6-3 2-6 6-4 |
| 1 | Daniela Hantuchova - Serra-Zanetti-Q | 6-4 6-4 |
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| New Haven Tier II Hard | Aug 26 2001 |
| Qual 1 | Serra-Zanetti - Emilie Loit | 4-6 7-5 7-5 |
| Qual 2 | Serra-Zanetti - Rita Grande(5) | 7-66 6-2 |
| Qual 3 | Anastasia Myskina - Serra-Zanetti | 6-3 6-4 |
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| US Open Hard | Sep 9 2001 |
| 1 | Jelena Dokic(14) - Serra-Zanetti | 6-2 3-6 6-2 |
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| Quebec City Tier III Hard | Sep 23 2001 |
| 1 | Serra-Zanetti - Abigail Spears-Q | 7-5 3-6 6-2 |
| 2 | Jennifer Hopkins(5) - Serra-Zanetti | 6-3 6-2 |
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| Moscow Tier I Carpet | Oct 7 2001 |
| Qual 1 | Dragana Zaric - Serra-Zanetti | 1-6 7-63 7-5 |
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| Shanghai Tier IV Hard | Oct 14 2001 |
| 1 | Rossana De Los Rios(9) - Serra-Zanetti | 6-2 6-3 |
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| Bratislava Tier IV Hard | Oct 21 2001 |
| Qual 1 | Serra-Zanetti(3) - Evelyn Fauth | 6-1 5-7 6-2 |
| Qual 2 | Serra-Zanetti(3) - Anastasia Rodionova | 4-6 6-2 7-5 |
| Qual 3 | Serra-Zanetti(3) - Aniko Kapros(5) | 6-2 6-3 |
| 1 | Serra-Zanetti-Q - Lubomira Kurhajcova-Q | 6-2 7-64 |
| 2 | Serra-Zanetti-Q - Eleni Daniilidou | 6-2 3-6 6-4 |
| QF | Serra-Zanetti-Q - Lilia Osterloh | 6-2 4-6 6-4 |
| SF | Martina Sucha-Q - Serra-Zanetti-Q | 5-7 6-1 6-1 |